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Cells keep the body healthy by devouring toxic waste to fight off everything from wrinkles to dementia. Could certain foods help?
Autophagy literally means “self-devouring” – something our cells are doing constantly, breaking down damage and toxic waste products – and Japanese cell biologist Yoshinori Ohsumi has just been awarded the Nobel prize in medicine for his work in uncovering the complex mechanisms that underpin this remarkable internal recycling system. So how does autophagy keep us healthy? Why might dysfunctional autophagy contribute to diabetes, dementia, leukaemia and Parkinson’s disease? And will our new understanding lead to any cures?
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Furthermore, autophagy levels fall in the ageing process. The characteristics of old age, such as wrinkles, hearing loss or cancer, are actually due to falling autophagy levels and the accumulation of toxic wastes in the cells.”
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Simon points out that cells switch on autophagy in response to starvation. Calorie restriction, such as intermittent fasting in the 5:2 diet or during Ramadan, may help us to live long and healthy lives. It is possible that reducing our calorie intake to 70% of what we have been used to eating will boost our autophagy and help to prevent a wide range of disease. Exercise also promotes more autophagy, as experiments that get mice to run on mini treadmills has shown.
Advice to feast on fruit, veg and red wine is hardly new. But thanks to this year’s Nobel prize-winner, our understanding of the science that underpins it is developing all the time. The next step will be drugs, supplements and interventions that could stave off the ravages of ageing and a host of debilitating diseases. We are not there yet, but we are one step closer.
https://www.theguardian.com/lifeand...-turmeric-and-red-grapes-the-key-to-long-life